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Valproic acid-associated chorea occurred in patients with severe epilepsy and brain damage.It may occur after several years of valproic acid use and may be more likely to develop if valproic acid is taken together with phenytoid.Because valproic acid-associated chorea seemed to be dose- related,avoiding excessive fluctuations of serum levels by the use of divalproex sodium sprinkles may be an effective solution in these cases. |
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